In message <1388164230.8.0.283533984591.issue2550827@psf.upfronthosting.co.za> 
<1388164230.8.0.283533984591.issue2550827@psf.upfronthosting.co.za>,
Matt writes:
>After upgrading to version 1.5.0 and removing this component from my
>host, I was no longer able to run as a windows service.
>
>Is this component still required in order to run Roundup Issue Tracker
>as a windows service?

The requirement for pywin32 seems to have been removed in the commit
referred to by this message:

  http://sourceforge.net/mailarchive/message.php?msg_id=30153584

What python vendor/version are you using?

Also can you start the server manually (i.e. not as a service).

When you try to run it as a service are there any tracebacks or event
logs?