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My point was that you should be able to just run:

 d:\> roundup-admin help initopts

assuming that the "d:\python22\scripts" directory is in your search path. It 
would presumably be added by the same mechanism that adds "d:\python22" 
to your path (Richard shrugs at how this is done on Windows).

Regardless, I've figured out what the problem is - it stems from the code that 
tries to determine the install prefix used to install the roundup package. The 
paths are slightly different on Windows to Un*x. Please try the attached 
admin.py to replace the one in your python lib dir (c:\python22\lib\site-
packages\roundup\admin.py)

I've also checked this new admin.py version into the CVS.